In this issue of Structure, Nojima et al. (2021) report the structure of the PGE-EP4-G complex by cryo-electron microscopy. This work shows unique modes of ligand binding, transduction mechanism, and G protein coupling of EP4, and serves as a starting point for development of more selective drugs.
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| http://dx.doi.org/10.1016/j.str.2021.02.003 | DOI Listing |
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