Understanding what regulates CD8 T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8 T cell immunity to engineer a more efficacious response against cancer and infections.
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| http://dx.doi.org/10.1016/j.cell.2021.02.003 | DOI Listing |
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