Antimicrobial Benzyltetrahydroisoquinoline-Derived Alkaloids from the Leaves of .

Four new alkaloids, ()-nomimantharine trifluoroacetate (), 12-demethylphaeantharine trifluoroacetate (), nominanthranal trifluoroacetate (), and the enolic form of 1-hydroxy-6,7-dimethoxy-2-methylisoquinoline trifluoroacetate (), together with the known dimeric alkaloid phaeantharine trifluoroacetate (), have been isolated from the extract of the leaves of the rainforest tree (Monimiaceae). The structures of these compounds were elucidated by HRMS and 1D and 2D NMR data. ()-Nomimantharine trifluoroacetate () contains an ether linkage connecting a benzylisoquinoline unit with a tetrahydroisoquinoline, a novel class of dimeric alkaloid. The absolute configuration of ()-nomimantharine trifluoroacetate () was established via electronic circular dichroism data. The compounds isolated were subjected to in vitro antimicrobial assays against a panel of pathogenic microorganisms, including , , , (SA), and five clinical isolates of oxacillin/methicillin-resistant (MRSA). Phaeantharine trifluoroacetate () and ()-nomimantharine trifluoroacetate () showed moderate inhibitory activities against and MRSA strains.