AI Article Synopsis

  • This study focused on the effects of polyphenol-rich TP 3-in-1™ juice, especially its anthocyanin content, on improving cognitive function and health in middle-aged women showing signs of cognitive decline.
  • Over a ten-week clinical trial with 31 participants, those who consumed the juice experienced significant improvements in cognitive tasks, such as memory recall and processing speed, compared to a placebo group.
  • Metabolomics analysis indicated that juice supplementation enhanced the excretion of specific metabolites linked to cognitive health, suggesting that TP 3-in-1™ juice may help combat cognitive issues related to aging and possibly the progression of Alzheimer's disease.

Article Abstract

Polyphenols, particularly anthocyanins, have received attention in improving health issues during old age, including decline in cognitive function and other health parameters. We aimed to determine the effects of polyphenols-rich tropical fruit TP 3-in-1™ juice towards improving cognitive function, oxidative stress and metabolomics profiles among middle-aged women. This clinical trial involved 31 subjects with signs of poor cognitive function, as assessed using the Rey Auditory Verbal Learning Test (RAVLT). They were randomized to receive either TP 3-in-1™ juice (= 16) or placebo (= 15). Study subjects consumed 500 ml of beverages for three times per day, three days per week, for a period of ten weeks. Juice supplementation provided 9135 mg GAE of total phenolic content and 194.1 mg cyanidin-3-glucoside of total anthocyanin monomer. There was a significant interaction effects on RAVLT immediate recall (< 0.05) and Comprehensive Trail Making Test (CTMT) Trail 4 ( < 0.05). Metabolomics analysis showed the presence of metabolites related to polyphenols intake and cognitive functions with the intervention group showed increased urinary excretion of thyroxine and 3-methyladenine. Thyroxine and 3-methyladenine give stability to human transthyretin (TTR) and activate autophagy, respectively, which are associated with the pathogenesis of Alzheimer's disease. The result shows the potential of TP 3-in-1™ juice which is rich in anthocyanins in improving cognitive function, particularly learning, memory, processing speed, sequencing, mental flexibility and visual-motor skills domains, among middle-aged women.

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Source
http://dx.doi.org/10.1080/1028415X.2021.1880312DOI Listing

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