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Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice. | LitMetric
The Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 ( ) or Notch3 ( ) in mice is not lethal. In fact, both and mice develop normally and are fertile. Here we present RNA seq analysis of differential gene expression in the kidneys of mice versus the mice, all on FVB background. Kidneys were collected from and littermates at 3 months of age. RNA sequencing was carried out. The raw data were analyzed for differential gene expression using a negative binomial generalized linear model in the DeSeq2 software package. We used -value ≤0.05 and an absolute fold change of 1.5 or greater to identify top upregulated and downregulated genes in mice compared to mice. The data provided will indentify targets of Notch3 and Notch4 signaling, specifically in kidney diseases where Notch3 or Notch4 are abberantly or redundantly expressed.
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