AI Article Synopsis
- - The study aimed to evaluate the effectiveness of a 24% sucrose gel compared to liquid sucrose and breastfeeding to reduce pain during heel prick procedures in neonates.
- - A total of 195 neonates were randomly assigned to receive either breastfeeding, liquid sucrose, or sucrose gel, with pain assessed using the Neonatal Infant Pain Scale.
- - Findings indicated that while all methods were effective, sucrose gel showed significantly lower odds of pain compared to liquid sucrose, suggesting it may be a suitable alternative when breastfeeding isn't an option.
Article Abstract
Objective: To compare sucrose 24% oral gel formulation to liquid formula and breastfeeding during a heel prick in neonates.
Study Design: In this comparative effectiveness research 195 neonates >36 weeks' gestation were randomised to three groups, receiving during heel stick: (i) breastfeeding, (ii) sucrose 24% liquid with non-nutritive sucking and (iii) sucrose 24% gel with non-nutritive sucking. The pain was assessed through the Neonatal Infant Pain Scale.
Results: All the methods analysed has shown to be effective in reducing pain. There was an increase in odds of pain following liquid sucrose compared to breastfeeding (OR = 1.60; 95% CI: 0.82-3.3; p = 0.17). A reduction of odds of pain was showed comparing sucrose to breastfeeding (OR = 0.78; 0.38-1.6; 0.48), and comparing sucrose gel to liquid formula (OR = 0.48; 0.23-0.96; p = 0.04).
Conclusion: Sucrose 24% gel with non-nutritive sucking seems to be a valid alternative when breastfeeding is not possible. Further research is needed.
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| http://dx.doi.org/10.1038/s41372-021-01025-6 | DOI Listing |
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