In this study, phytochemical investigation on the chloroform soluble fraction of seed kernels of led to the isolation of two new cassane-type diterpenoids, norcaesalpinin Q () and caesalpinin MR (), together with seven known compounds (-). The structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. All compounds were evaluated for inhibitory effects against NO production of RAW264.7 cells induced by LPS, and compounds , and could inhibited the production of NO at the concentration of 50 µM.
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Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities.
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Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650504, China. Electronic address:
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School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China. Electronic address:
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