AI Article Synopsis
- Radioiodine (Iodine-131) ablation is commonly used to treat differentiated thyroid cancer after thyroid removal, but it can lead to rare liver damage.
- A study of 94 patients examined the effects of this treatment on those with and without hepatitis B virus (HBV) infections, finding that HBV-infected patients experienced higher rates of hepatotoxicity.
- The research concluded that HBV infection is a significant risk factor for liver damage in post-surgical thyroid cancer patients receiving radioiodine therapy, indicating the need for doctors to monitor liver function closely in these patients.
Article Abstract
Objective: Radioiodine (Iodine-131, I) ablation is a standard treatment for differentiated thyroid cancer (DTC) after thyroidectomy. Hepatotoxicity is a rare side effect of I, and little information is available on the hepatotoxicity of I ablation for post-surgical DTC patients with hepatitis B virus (HBV) infection.
Methods: We performed a retrospective study of 94 post-surgical DTC patients between November 2012 and August 2015 in our hospital. All the patients had been screened for HBV infection and divided into HBV group and non-HBV group. Clinical data were compared between the two groups.
Results: 14 patients with HBV infection and 80 patients without HBV infection were analyzed. The baseline characteristics of the two groups had no statistical differences. Incidence of hepatotoxicity was higher in HBV group than in non-HBV group and HBV infection was confirmed as a risk factor of hepatotoxicity by univariate and multivariate regression analysis.
Conclusion: Post-surgical DTC patients with HBV infection were prone to hepatotoxicity by I ablation treatment. Physicians should pay more attention to the liver function of patients at risk.
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| http://dx.doi.org/10.1016/j.clinre.2021.101631 | DOI Listing |
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