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Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2. | LitMetric

Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2.

Nanomedicine

Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, SLP, Mexico; Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, SLP, Mexico. Electronic address:

Published: June 2021

The development of vaccines is a crucial response against the COVID-19 pandemic and innovative nanovaccines could increase the potential to address this remarkable challenge. In the present study a B cell epitope (S) from the spike protein of SARS-CoV-2 was selected and its immunogenicity validated in sheep. This synthetic peptide was coupled to gold nanoparticles (AuNP) functionalized with SH-PEG-NH via glutaraldehyde-mediated coupling to obtain the AuNP-S candidate, which showed in s.c.-immunized mice a superior immunogenicity (IgG responses) when compared to soluble S; and led to increased expression of relevant cytokines in splenocyte cultures. Interestingly, the response triggered by AuNP-S was similar in magnitude to that induced using a conventional strong adjuvant (Freund's adjuvant). This study provides a platform for the development of AuNP-based nanovaccines targeting specific SARS-CoV-2 epitopes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920803PMC
http://dx.doi.org/10.1016/j.nano.2021.102372DOI Listing

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