We report the synthesis of a peptide nucleic acid (PNA) monomer containing preQ, a positively charged guanine analogue. The new monomer was incorporated into PNA oligomers using standard Fmoc-chemistry-based solid-phase synthesis. The preQ unit-containing PNA oligomers exhibited improved affinity for their complementary DNA through electrostatic attraction, and their sequence specificity was not compromised. It could be beneficial to incorporate preQ into PNA oligomers instead of guanine when creating antisense/antigene agents or research tools.
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| http://dx.doi.org/10.1016/j.bmcl.2021.127850 | DOI Listing |
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