AI Article Synopsis
- The study investigates the relationship between the geometry of ruptured coronary plaques and the occurrence of acute coronary syndrome (ACS) using advanced computational fluid dynamics (CFD) in patients with coronary artery disease.
- It involved 45 patients where three-dimensional intravascular ultrasound (IVUS) images were analyzed to compare blood flow profiles around ruptured plaques in those with provoked ACS versus those without.
- Results indicated that blood flow was more stagnant around plaques that caused ACS compared to silent ruptures, suggesting that differing flow characteristics may contribute to the risk of ACS.
Article Abstract
Aim: Coronary plaque rupture is the main cause of acute coronary syndrome (ACS), but the role of blood flow features around plaque rupture for ACS is still unknown. The present study aimed to assess the relationship between the geometric configuration of ruptured plaque and ACS occurrence using computational fluid dynamics (CFD) by moving particle method in patients with coronary artery disease.
Methods: In this study, 45 patients with coronary artery disease who underwent three-dimensional intravascular ultrasound (IVUS) and had a coronary ruptured plaque (24 plaques with provoked ACS, 21 without) were included. To compare the difference in blood flow profile around ruptured plaque between the patients with and without ACS, the IVUS images were analyzed via the novel CFD analysis.
Results: There were no significant differences in localized flow profile around ruptured plaque between the two groups when the initial particle velocity was 10.0 cm/s corresponded to a higher coronary flow velocity at ventricular diastole. However, when it was 1.0 cm/s corresponded to lower coronary flow velocity at ventricular systole, particles with lower velocity (0 ≤ V ≤ 5 cm/s) were more prevalent around ACS-PR ( p=0.035), whereas particles with higher velocity (10 ≤ V ≤ 20 cm/s) were more often detected in silent plaque ruptures (p=0.018).
Conclusions: Three-dimensional IVUS revealed that coronary plaque rupture was a complex one with a wide variety of its stereoscopic configuration, leading to various patterns of the local coronary flow profile. A novel CFD analysis suggested that the local flow was more stagnant around ACS-provoked ruptures than in silent ones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090478 | PMC |
| http://dx.doi.org/10.5551/jat.60509 | DOI Listing |
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