Uterine leiomyoma represents the most common pelvic tumor in females, including numerous histological subtypes, from which smooth muscle tumors of uncertain malignancy potential (STUMP) represents the diagnostic challenge. On the other hand, the study of the relapse risk markers after laparoscopic myomectomy is of high interest. We investigated the molecular phenotype of different types of leiomyoma after hysterectomy or laparoscopic surgery in reproductive and menopausal women. Standard immunohistochemistry was used to detect proliferation markers Ki67 and cyclin D1, apoptotic markers Bcl2 and Cas3, and ER and PR. The results of our study indicated that ER expression is significantly higher in relapsed leiomyoma, compared to control group. In addition, relapsed leiomyomas are characterised with high proliferation and apoptotic index. With regard to STUMP despite histological homogeneity, this entity is characterised with the presence of three distinct molecular subtypes, based on proliferation and apoptotic marker expression, which should be used as diagnostic aid in these tumors.
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View Article and Find Full Text PDFArticle Synopsis
- Uterine leiomyomas can sometimes lead to serious conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE), even in patients with no known risk factors.
- A 38-year-old woman experienced leg swelling, pain, and breathing difficulties and was diagnosed with DVT and PE, which were confirmed through imaging.
- The treatment involved mechanical thrombectomy and hysterectomy, resulting in a full recovery with no recurrence of thromboembolic events after 11 months.
Uterine Smooth Muscle Tumor of Undetermined Malignant Potential (STUMP): A Diagnostic Challenge.
Cureus
November 2024
Medical Oncology, Tata Main Hospital, Jamshedpur, IND.
Article Synopsis
- Smooth muscle tumors of the uterus vary from benign leiomyomas to malignant leiomyosarcomas, with STUMP representing a challenging gray area of tumors with uncertain malignant potential.
- A case study is presented of a 52-year-old woman with severe menorrhagia, diagnosed with STUMP after a hysteroscopy and biopsy, which raised concerns about the possibility of leiomyosarcoma.
- The patient underwent a radical hysterectomy, where the final diagnosis remained STUMP, and has since been on regular follow-up without any recurrence, highlighting the rarity of STUMP presenting as a uterine polyp.
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