The aim of the study was to assess general characteristics of drug resistant tuberculosis and its association with treatment outcomes in Georgia. A retrospective cohort study was conducted among 1581 DR-TB adult (18+) patients, from 2015 - 2020 cohorts, whose anti-tuberculosis treatment outcomes was known. Adjusted analysis of the study participants data [1581 (100%)] shows significant association of a successful TB treatment outcome with the "Female gender" (adjusted OR 1.78, 95% CI: 1.33 - 2.39, p<0.001), "New TB case" (adjusted OR 2.34, 95% CI: 1.88-2.91, p<0.001) and with "HIV negative status" (OR 2.33; 95% CI 1.53-3.55; p<0.001). Based on bivariate and multivariate analysis of the study data, the significant association of a treatment outcome with other key factors, including "New drugs in the regimen" was not found. Since the programmatic using of the new effective DR-TB regimens are widely recommended only from 2019, the treatment outcomes of all patients on these regimens are still not defined. Further studies are necessary to assess complete data of the patients on new DR-TB regimens and its association with the treatment outcomes.
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BMC Pharmacol Toxicol
January 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective: Cyclin-dependent kinase (CDK)-4/6 inhibitors have significantly improved outcomes in several cancers but can also induce various organ system toxicities, including musculoskeletal disorders. This study aimed to comprehensively characterize the musculoskeletal adverse events (MSAEs) associated with CDK4/6 inhibitors based on real-world data.
Methods: Reports of MSAEs linked to CDK4/6 inhibitors from the first quarter (Q1) of 2015 and 2023 Q4 were extracted from the FAERS.
J Cardiothorac Surg
January 2025
Department of Cardiology, The first Affiliated Hospital of Wannan, Medical College, Wuhu, China.
Background: He's team have recently developed a new Coronary Artery Tree description and Lesion EvaluaTion (CatLet) angiographic scoring system, which is capable of accounting for the variability in coronary anatomy, and risk-stratifying patients with coronary artery disease. Preliminary studies have demonstrated its superiority over the the Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score with respect to outcome predictions for acute myocardial infarction (AMI) patients. However, there are fewer studies on the prognostic in chronic coronary artery disease(CAD).
View Article and Find Full Text PDFTrop Med Health
January 2025
Department of Medical Research, Ministry of Health, No.5, Ziwaka Road, Dagon Township, Yangon, 11191, Myanmar.
Background: Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur. Adults are more likely than children to experience co-infections of dengue and other diseases.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Background: Glia mediated neuroinflammation and degeneration of inhibitory GABAergic interneurons are some of the hall marks of pyrethroid neurotoxicity. Here we investigated the sex specific responses of inflammatory cytokines, microglia, astrocyte and parvalbumin positive inhibitory GABAergic interneurons to λ-cyhalothrin (LCT) exposures in rats.
Methods: Equal numbers of male and female rats were given oral corn oil, 2 mg/kg.
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