The aim of this study was to investigate the features of bone metabolism and their influence on the arterial wall stiffness in postmenopausal women with a controlled uncomplicated arterial hypertension (AH). The study involved 44 women (main group) with the mean age of 69.04±0.72 years and a postmenopausal duration of 18.4±0.85 years, suffering from an AH grade 2, and 30 healthy patients (control group), their mean age being 69.3±1.21 years, postmenopausal duration 19.4±1.18 years (p>0.05). All patients underwent general clinical and laboratory examination with determination of lipid level in blood. Pulse wave analysis (SphygmoCor) parameters , Bone mineral density (BMD) were assessed. The levels of 25(OH) D, parathyroid hormone, propeptide procollagen of type 1 aminoterminal (P1NP), b-isomerized C-terminal telopeptides (b-CTx), ionized calcium and phosphorus in serum were assessed. The data obtained from the study of the parameters of applanation tonometry and the structural and functional state of bone tissue in patients with an uncomplicated hypertension at the age of 69±3.30 years manifest the likelihood of joint pathogenetic mechanisms of developing atherocalcinosis, increased vascular stiffness and impending osteoporosis.
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