TRANSFORMING GROWTH FACTOR AND ARTERIAL STIFFNESS IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION.

The aim of our study was to identify the relationship between TGF-β1, arterial stiffness, and target organ damage in patients with uncontrolled arterial hypertension (UAH). The study included 140 patients with hypertension: 30 people with uncontrolled hypertension (UAH), 80 people with controlled hypertension (CAH) and 30 people in the control group. All patients underwent determination of arterial stiffness using cardio-ankle vascular index (CAVI) and TGF-β1 level. The TGF-β1 level was 19,2 [17,2; 24,7] ng/ml in the CAH group. In the UAH group - 22,6 [20,6; 25,6] ng/ml. In the control group - 17.4 [11,8; 19,3] ng/ml. The maximum and minimum values of the CAVI indices were observed in the group UAH 9,2 [8,5; 9,9] and control group 7 [6,5; 7,5], respectively (p<0,05), in the CAH group there was an intermediate value of the CAVI index 7.8 [7,0; 8,5] (p<0,05). The correlation analysis revealed a significant relationship between the TGF-β1 level and CAVI for patients with hypertension (CAG r=0,777; NAG r=0,753; p<0.05). There was a significant difference in the TGF-β1 levels depending on the stage of hypertension in patients CAH (p <0,05). According to the results of the one-way regression analysis, it was revealed that in hypertensive patients with a TGF-β1 value, the most significant interactions are between myocardial mass (MM) (p<0,05), CAVI (p<0,05) and creatinine (p<0,05). An increase in the concentration of TGF-β1 and an increase of arterial stiffness were revealed in patients of the UAH group in comparison with the other groups. The relationship between TGF-β1 and arterial stiffness was also found.