AI Article Synopsis
- - Three new alkaloids were discovered from the seeds of Sophora alopecuroides L., namely 8β-hydroxyoxysophoridine, 9β-hydroxysophoridine, and 9β-hydroxyisosophocarpine, along with a known compound, 11,12-dehydromatrine.
- - The structures of these new compounds were determined using advanced spectroscopic techniques, including experimental and calculated ECD (Electronic Circular Dichroism) data.
- - Testing for anti-inflammatory properties revealed that 8β-hydroxyoxysophoridine exhibited a notable inhibitory effect on NO production in stimulated RAW 264.7 cells, with an IC value
Article Abstract
Three new matrine-type alkaloids, 8β-hydroxyoxysophoridine (1), 9β-hydroxysophoridine (2), 9β-hydroxyisosophocarpine (3), together with one known analog, 11,12-dehydromatrine (4), were isolated from the seeds of Sophora alopecuroides L. The structures of new compounds were elucidated using extensive spectroscopic techniques including the experimental and calculated ECD data. The anti-inflammatory activities of all the isolates on NO production in RAW 264.7 cells stimulated by lipopolysaccharide were evaluated. Among them, 8β-hydroxyoxysophoridine (1) showed a significant inhibitory effect with an IC value of 18.26 μM.
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| http://dx.doi.org/10.1002/cbdv.202001066 | DOI Listing |
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