AI Article Synopsis
- Five matrine-type alkaloids were extracted from Sophora tonkinesis roots, including two new compounds and a new natural product.
- Their structures were confirmed using various spectroscopic methods and X-ray diffraction determined the absolute configurations of two compounds.
- Compound 1 demonstrated the strongest anti-inflammatory activity by reducing TNF-α and IL-6 levels in macrophages, outperforming matrine, the main active ingredient in Sophora plants.
Article Abstract
Five matrine-type alkaloids (1‒5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic analysis (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction. Compounds 1‒5 were evaluated their activity against inflammatory cytokines TNF-α and IL-6 levels on LPS-induced RAW 264.7 macrophages, and compound 1 showed the most significant activity, potent than that of matrine, the representative ingredient from Sophora plants.
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| http://dx.doi.org/10.1007/s11418-021-01498-x | DOI Listing |
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