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Acute Kidney Injury Post Hip Fracture Surgery: Local Quality Improvement Project and Review of Literature.
Cureus
December 2024
Trauma and Orthopaedics, University Hospitals Sussex National Health Service (NHS) Foundation Trust, Sussex, GBR.
Background: The aim of the study is to identify the potential risk factors for postoperative AKI in hip fracture patients.
Design And Methods: Using our local neck of femur (NOF) registration data, patient details were selected using inclusion and exclusion criteria. Electronic records of patients were assessed retrospectively, including blood results, radiological investigations, clinical documentation, and drug charts.
The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.
J Ayurveda Integr Med
January 2025
Department of Pharmacy, Universitas Sriwijaya, South Sumatera, Indonesia.
Background: Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.
Objective: This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.
Chemoprotective Mechanism of Sodium Thiosulfate Against Cisplatin-Induced Nephrotoxicity Is via Renal Hydrogen Sulfide, Arginine/cAMP and NO/cGMP Signaling Pathways.
Int J Mol Sci
January 2025
Department of Animal Experimentation, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra P.O. Box LG581, Ghana.
Cisplatin is a common and highly effective chemotherapeutic agent whose nephrotoxic side effect is well-characterized. Sodium thiosulfate (STS), an FDA-approved hydrogen sulfide (HS) donor drug, is emerging as a chemoprotective agent against cisplatin-induced nephrotoxicity (CIN). In this study, we investigated the chemoprotective mechanism of STS in a rat model of CIN.
View Article and Find Full Text PDFAcute kidney injury following CAR-T cell therapy: a nephrologist's perspective.
Clin Kidney J
January 2025
Department of Medicine, Universidad Autonoma de Madrid and IIS-Fundacion Jimenez Diaz, Madrid, Spain.
Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized immunotherapy for various haematologic malignancies, autoimmune diseases and other conditions, involves the modification of patients' T cells to express a chimeric antigen receptor that recognizes tumour or autoimmune cell antigens, allowing CAR-T cells to destroy cancerous and other target cells selectively. Despite remarkable clinical improvements in patients, multiple adverse effects have been associated with CAR-T cell therapy. Among the most recognized adverse effects are cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and tumour lysis syndrome.
View Article and Find Full Text PDFIn vivo systemic vancomycin determination from polymethyl methacrylate and morselized bone allograft used in two stage septic knee revision arthroplasty.
Germs
September 2024
MD, PhD, Professor, Department of Orthopedics, Carol Davila University of Medicine and Pharmacy, No. 8 Eroii Sanitari Boulevard, Bucharest, 050474, Romania.
Introduction: This paper examines the use of local antibiotic therapy in one-stage septic revision surgery for late periprosthetic joint infections (PJIs). This case study suggests that morselized bone allografts impregnated with antibiotics in powder form are a preferable alternative to polymethyl methacrylate (PMMA) because they can generate higher local antibiotic concentrations. Current research also recommends using vancomycin and aminoglycosides as the preferred choice of antibiotics, as they may have low diffusion in tissues when administered intravenously, but are effective when administered locally.
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