AI Article Synopsis
- The study explores the unclear relationship between cancer and dementia, highlighting issues like survivor bias and confounding factors.
- Using the Memento cohort, researchers gathered data from individuals with cognitive complaints over a median of 5 years to analyze the association between cancer and dementia.
- Findings suggest that developing cancer is associated with a reduced risk of dementia, indicating a potential protective relationship that warrants further investigation.
Article Abstract
Introduction: Studies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding.
Methods: This study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness-death models (IDMs) were used to estimate transition-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry.
Results: The analytical sample (N = 2258) excluded 65 individuals without follow-up information. At the end of follow-up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35-0.97), with a corresponding E-value of 2.84 (lower CI = 1.21).
Discussion: This study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518910 | PMC |
| http://dx.doi.org/10.1002/alz.12308 | DOI Listing |
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