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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">33655880</PMID><DateCompleted><Year>2022</Year><Month>05</Month><Day>17</Day></DateCompleted><DateRevised><Year>2022</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1874-4729</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>2</Issue><PubDate><Year>2022</Year></PubDate></JournalIssue><Title>Current radiopharmaceuticals</Title><ISOAbbreviation>Curr Radiopharm</ISOAbbreviation></Journal><ArticleTitle>Media Fill Test for Validation of Non-Radioactive Kit for Radiopharmaceutical Preparations.</ArticleTitle><Pagination><StartPage>104</StartPage><EndPage>109</EndPage><MedlinePgn>104-109</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2174/1874471014666210303152908</ELocationID><Abstract><AbstractText Label="INTRODUCTION">The administration of improperly prepared intravenous fluids might determine healthcare-associated infections. Quality and sterility assurance in radiopharmaceutical manufacturing products must be evaluated by media fill tests that simulate the performance of the aseptic manufacturing procedure. The aim of this study is to show a methodological modification of a specific step of media fill tests, giving an overview of economic and organizational advantages that it might bring.</AbstractText><AbstractText Label="MATERIALS AND METHODS">Media fill tests were conducted to ensure that they reproduce as strictly as possible the routine aseptic production process with all the critical steps described in the internal Standard Operating Procedures. We introduced an innovative modification in step 1: instead of using a completely decayed <sup>99</sup>Mo/<sup>99m</sup>Tc generator, we used a<sup>99</sup>Mo/<sup>99m</sup>Tc generator just before its disposal, eluting it with saline solution aspirated in an empty vacuum vial.</AbstractText><AbstractText Label="RESULTS">A total of 47 production runs were performed, and a total of 799 vials were tested for sterility. Thirteen nuclear medicine technicians were assessed. We found contamination in 1% of the total number of vials analyzed.</AbstractText><AbstractText Label="CONCLUSIONS">The modification proposed shows several advantages: reduction of the costs of the media fill tests, the possibility to manage these without referring to external services, and decreased injuries for technicians who perform the tests.</AbstractText><CopyrightInformation>Copyright&#xa9; Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vincenti</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Women and Child Health and Public Health -Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scotognella</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Unit of Nuclear Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruno</LastName><ForeName>Stefania</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Sezione di Igiene, Istituto di Sanit&#xe0; Pubblica, Universit&#xe0; Cattolica del Sacro Cuore; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariani</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sezione di Igiene, Istituto di Sanit&#xe0; Pubblica, Universit&#xe0; Cattolica del Sacro Cuore; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boninti</LastName><ForeName>Federica</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Women and Child Health and Public Health -Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cambieri</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Direzione Sanitaria, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Damiani</LastName><ForeName>Gianfranco</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Sezione di Igiene, Istituto di Sanit&#xe0; Pubblica, Universit&#xe0; Cattolica del Sacro Cuore; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurenti</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Women and Child Health and Public Health -Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Sezione di Igiene, Istituto di Sanit&#xe0; Pubblica, Universit&#xe0; Cattolica del Sacro Cuore; Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giordano</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Nuclear Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS; Roma, Italia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Radiopharm</MedlineTA><NlmUniqueID>101468718</NlmUniqueID><ISSNLinking>1874-4710</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004340" MajorTopicYN="N">Drug Contamination</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention &amp; control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007246" MajorTopicYN="Y">Infertility</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019275" MajorTopicYN="Y">Radiopharmaceuticals</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Mediafill tests</Keyword><Keyword MajorTopicYN="N">aseptic assurance</Keyword><Keyword MajorTopicYN="N">healthcare associated infections</Keyword><Keyword MajorTopicYN="N">microbial contamination</Keyword><Keyword MajorTopicYN="N">nonradioactive</Keyword><Keyword MajorTopicYN="N">sterile products</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>1</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>1</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2022</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>3</Day><Hour>8</Hour><Minute>42</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33655880</ArticleId><ArticleId IdType="doi">10.2174/1874471014666210303152908</ArticleId><ArticleId IdType="pii">CRP-EPUB-114725</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>