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| http://dx.doi.org/10.11604/pamj.2020.37.312.26813 | DOI Listing |
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Background: The proportion of people living with HIV (PLHIV) in Guangxi who are men who have sex with men (MSM) increased rapidly to nearly 10% in 2023; notably, over 95% of this particular population is currently receiving antiretroviral therapy (ART). This study aimed to describe the survival of MSM PLHIV, depict the characteristics and trends of changes in CD4 T cell counts, CD4/CD8 T cell ratio, and viral load, and explore immunological indicators that may be related to mortality during different stages of treatment.
Methods: Immunological indicators of MSM PLHIV receiving ART were extracted and categorized into baseline, mid-treatment, and last values.
Association between changes in genital immune markers and vaginal microbiome transitions in bacterial vaginosis.
Sci Rep
January 2025
Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit St, Their 9, Boston, MA, 02114, USA.
Bacterial vaginosis (BV), characterized by an imbalance in the vaginal microbiota, is a prevalent condition among women of reproductive age and a risk factor for human immunodeficiency virus, sexually transmitted infections, and preterm birth. BV is generally considered to induce mucosal inflammation, but the specific pathways and cell types involved are not well characterized. This prospective study aimed to assess associations between microbial changes and mucosal immune responses in BV patients.
View Article and Find Full Text PDFBisphenol F (BPF) exposure impairs sperm quality and offspring development in male zebrafish.
Toxicol Appl Pharmacol
January 2025
Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, Guangdong, China. Electronic address:
Background: Bisphenol F (BPF), a substitute for bisphenol A (BPA), is widely used in consumer products, increasing the potential for environmental exposure. Our study investigated the reproductive effects of BPF on adult male zebrafish and explored its toxicological mechanisms, as well as its intergenerational effects.
Methods: Adult male zebrafish were exposed to BPF concentrations of 0, 50, 500, 2500, and 5000 nM for 21 days.
Sexual dimorphism in right ventricular adaptation to pressure overload involves differential angiogenic response.
Am J Physiol Heart Circ Physiol
January 2025
Department of Physiology and Biophysics, Dalhousie University, Halifax, NS.
This study investigated the sexual dimorphism in right ventricle (RV) remodeling in right heart failure susceptible Fischer CDF rats using the pulmonary artery banding (PAB) model. Echocardiography and hemodynamic measurements were performed in adult male and female Fischer CDF rats at 1- or 2-weeks post-PAB. RV systolic pressure and RV hypertrophy were significantly elevated in PAB rats compared to sham control at 1- and 2-weeks post-PAB; however, no differences were observed between male and female rats.
View Article and Find Full Text PDFAging women in Russia: Between sexless and sexy oldies.
J Women Aging
January 2025
Department of Sociology, European University at St. Petersburg, St Petersburg, Russia.
Women's sexuality as a dimension of embodied identity is shaped and constrained by social norms of gender and age and negotiated by women in complex ways. Discourses of hegemonic bodily normativity ascribe a sexless subjectivity to Russian women in their post-reproductive years, contributing to their social exclusion. At the same time, in modern Russian society a neoliberal concept of "successful active aging" is gradually changing understandings of aging, making later-life sexuality more visible and legitimate.
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