AI Article Synopsis
- The study focuses on the effectiveness of preoperative neoadjuvant therapy in improving outcomes for patients with locally advanced rectal cancer, highlighting that pathological findings post-treatment may be more predictive of survival than clinical TNM stage.
- A total of 3026 patients from two hospitals were analyzed, with models created to predict overall survival (OS) and disease-free survival (DFS) based on significant predictors found in the data.
- The results indicated that nomograms developed from these pathological findings accurately predicted 3-year OS and DFS rates, demonstrating their reliability as tools for assessing patient prognosis.
Article Abstract
Purpose: Preoperative neoadjuvant therapy is standard before surgery for locally advanced rectal cancer in current clinical treatment. However, patients with the same clinical TNM stage before treatment vary in clinical outcomes. More and more studies noted that pathological findings after preoperative neoadjuvant therapy are better prognostic factors to determine prognosis than clinical TNM stage in patients with locally advanced rectal cancer. The purpose of this study is to develop and validate models based on pathological findings to predict overall survival (OS) and disease-free survival (DFS).
Patients And Methods: A total of 3026 patients from two hospitals were included. The endpoint was OS and DFS. Significant predictors of OS on multivariate analysis were used to establish the nomogram.
Results: The Harrell's C index for OS prediction was 0.72 (95% confidence interval [CI], 0.68 to 0.77) in the training cohort, 0.66 (95% CI, 0.60 to 0.72) and 0.68 (95% CI, 0.64 to 0.73) in the internal and external validation cohorts. Using this nomogram, high- and low-risk groups for OS were defined in the training cohort. The 3-year OS was 78.1% (95% CI: 72.4-84.2%) for the high-risk group and 95% (95% CI: 93.6-96.5%) in the low-risk group (HR: 4.42, 95% CI: 3.22-6.05; P<0.001). This finding was also applied in the two external cohorts. Similarly, a nomogram that contained the same indices was developed and validated to predict for DFS.
Conclusion: Nomograms based on pathological findings are a reliable tool to predict 3-year OS and DFS rate in patients with locally advanced rectal cancer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910108 | PMC |
| http://dx.doi.org/10.2147/CMAR.S296593 | DOI Listing |
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