Red blood cells (RBCs) capability to deliver oxygen (O) has been routinely measured by P50. Although this defines the ability of RBCs to carry O under equilibrium states, it cannot determine the efficacy of O delivery in dynamic blood flow. Here, we developed a microfluidic analytical platform (MAP) that isolates single RBCs for assessing transient changes in their O release rate. We found that in vivo (biological) and in vitro (blood storage) aging of RBC could lead to an increase in the O release rate, despite a decrease in P50. Rejuvenation of stored RBCs (Day 42), though increased the P50, failed to restore the O release rate to basal level (Day 0). The temporal dimension provided at the single-cell level by MAP could shed new insights into the dynamics of O delivery in both physiological and pathological conditions.
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| http://dx.doi.org/10.1038/s42003-021-01793-z | DOI Listing |
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