Non-shared environmental variance (NSEV) accounts for 76% of variance in genetic modelling of handedness. However, it is very misleading to suggest that NSEV, "highlights the importance of non-genetic factors for the ontogenesis of hemispheric asymmetries". NSEV is poorly named, is calculated only by subtraction, and provides no direct evidence for environmental effects in the sense of the external environment. Miller suggested that it would be better named as "residual effect". Mitchell has suggested that much or indeed most of NSEV is "developmental variance" and should be included under the heading of nature rather than nurture, and in handedness, "largely reflect[s] the outcome of randomness in brain development". Overall only a very small proportion of NSEV in handedness is likely to be related to external environmental factors in the usual sense of the term.
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http://dx.doi.org/10.1080/1357650X.2021.1892126 | DOI Listing |
Adv Biol (Weinh)
December 2024
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK.
Extracellular vesicles (EVs) are components of the senescence-associated secretory phenotype (SASP) that influence cellular functions via their cargo. Here, the interaction between EVs derived from senescent (SEVs) and non-senescent (N-SEVs) fibroblasts and the immune system is investigated. Via endocytosis, SEVs are phagocytosed by monocytes, neutrophils, and B cells.
View Article and Find Full Text PDFSci Transl Med
March 2021
Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, PR China.
Stem cell-derived small extracellular vesicles (sEVs) promote angiogenesis after myocardial infarction (MI). However, the components of sEVs that contribute to these effects and the safety and efficiency of engineered sEV treatment for MI remain unresolved. Here, we observed improved cardiac function, enhanced vascular density, and smaller infarct size in mice treated with the sEVs from hypoxia-preconditioned (HP) mesenchymal stem cells (MSCs) (HP-sEVs) than in mice treated with normoxia-preconditioned (N) MSCs (N-sEVs).
View Article and Find Full Text PDFLaterality
May 2021
Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Non-shared environmental variance (NSEV) accounts for 76% of variance in genetic modelling of handedness. However, it is very misleading to suggest that NSEV, "highlights the importance of non-genetic factors for the ontogenesis of hemispheric asymmetries". NSEV is poorly named, is calculated only by subtraction, and provides no direct evidence for environmental effects in the sense of the external environment.
View Article and Find Full Text PDFACS Omega
December 2019
The Pq Laboratory of Micro/Nano BiomeDx, Department of Biomedical Engineering, Binghamton University-SUNY, Binghamton, New York 13902, United States.
Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles of submicron size that are secreted by various cells. As mediators of intercellular communication, EVs can alter the physiological state of recipient cells by delivering encapsulated proteins and nucleic acids. Incontestably, growing evidence has shown important biological roles and the clinical relevance of EVs.
View Article and Find Full Text PDFNicotine Tob Res
December 2019
Department of Social and Behavioral Sciences, College of Global Public Health, New York University, New York, NY.
Background: Pervasive misperceptions about nicotine may influence uptake of quit smoking aids and the impact of policies addressing nicotine as a tobacco product constituent.
Methods: Latent class analyses were conducted using four items on nicotine beliefs asked of 4037 adults aged 18-40 in wave 9 (February-March 2016) of the Truth Initiative Young Adult Cohort Study. Confirmatory factor analyses identified three factors from 12 items: nicotine susceptibility (NSUS), nicotine severity (NSEV), and tobacco severity (TSEV).
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