AI Article Synopsis
- MACC1 is identified as a significant biomarker for predicting metastasis in over 20 types of solid cancers, but its influence on cancer metabolism had not been thoroughly studied.
- The research highlights how MACC1 affects the metabolism of key nutrients like glucose, glutamine, lactate, pyruvate, and fatty acids, showcasing its role in enhancing nutrient uptake and modifying metabolic pathways.
- The findings suggest that MACC1 is a crucial player in regulating cancer cell metabolism, enabling changes in nutrient utilization and the turnover of metabolic products.
Article Abstract
MACC1 is a prognostic and predictive metastasis biomarker for more than 20 solid cancer entities. However, its role in cancer metabolism is not sufficiently explored. Here, we report on how MACC1 impacts the use of glucose, glutamine, lactate, pyruvate and fatty acids and show the comprehensive analysis of MACC1-driven metabolic networks. We analyzed concentration-dependent changes in nutrient use, nutrient depletion, metabolic tracing employing C-labeled substrates, and in vivo studies. We found that MACC1 permits numerous effects on cancer metabolism. Most of those effects increased nutrient uptake. Furthermore, MACC1 alters metabolic pathways by affecting metabolite production or turnover from metabolic substrates. MACC1 supports use of glucose, glutamine and pyruvate via their increased depletion or altered distribution within metabolic pathways. In summary, we demonstrate that MACC1 is an important regulator of metabolism in cancer cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956336 | PMC |
| http://dx.doi.org/10.3390/cancers13050978 | DOI Listing |
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