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Evaluation of the Cerebrospinal Fluid (CSF)-Truenat Assay: A Novel Chip-Based Test in the Diagnosis and Management of Tubercular Meningitis at a Tertiary Care Hospital.
Cureus
November 2024
Emergency Medicine, Sarojini Naidu Medical College, Agra, IND.
Introduction: Tuberculosis (TB) continues to be a major health concern that has a significant impact on morbidity and mortality worldwide. Tubercular meningitis (TBM) may be fatal due to its severe neurological outcomes if not diagnosed and treated promptly. The newer molecular diagnostic techniques have brought significant advancements in the detection of (MTB).
View Article and Find Full Text PDFDiagnostic accuracy of Truenat MTB Plus, Truenat MTB Ultima and Xpert MTB/RIF Ultra for the diagnosis of pulmonary TB in an HIV-endemic setting.
Res Sq
September 2024
DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Article Synopsis
- Truenat MTB Plus and MTB Ultima are WHO-approved tests for tuberculosis, but their performance data are limited, prompting a study in Cape Town, South Africa with 498 participants.
- The study compared the accuracy of these tests against the Xpert MTB/RIF Ultra using culture as the reference standard, revealing sensitivities of 84% for MTB Plus, 90% for Ultima, and 92% for Ultra, with varying specificities.
- While Ultima showed similar sensitivity to Ultra, both tests had significant rates of unsuccessful results and exhibited variability based on lot differences, indicating that improvements are needed in their reliability for TB detection.
Diagnostic evaluation of Tru-Nat MTB/Rif test in comparison with microscopy for diagnosis of pulmonary tuberculosis at tertiary care hospital of eastern Uttar Pradesh.
Iran J Microbiol
August 2024
Department of Microbiology, All India Institute of Medical Science (AIIMS) Gorakhpur, Uttar Pradesh, India.
Background And Objectives: This study evaluated the efficacy of the TrueLab™ Real Time mini-PCR system in providing rapid and accurate diagnostic results for tuberculosis (TB) detection in India. The goal is to improve case detection and accelerate treatment in settings with limited resources.
Materials And Methods: This prospective study was conducted by the Department of Microbiology on 120 patients, age ranging from >=15 years with at least two clinical symptoms of pulmonary TB.
Diagnostic accuracy of truenat MTB plus for the detection of pulmonary and extrapulmonary tuberculosis.
Indian J Med Microbiol
September 2024
Department of Microbiology, Believers Church Medical College Hospital, Thiruvalla, Kerala, India.
Article Synopsis
- Traditional TB diagnostic tests have limitations in performance and speed, prompting the development of rapid molecular tests like the Truenat MTB Plus assay in India.
- This study evaluates the diagnostic accuracy of Truenat MTB Plus for both pulmonary TB (PTB) and extrapulmonary TB (EPTB) by comparing it to traditional culture methods.
- Results show that Truenat MTB Plus exhibits high sensitivity (90% for PTB and 81.8% for EPTB) and specificity (98.2% for PTB and 97.4% for EPTB), making it a reliable option, particularly in resource-limited settings.
Evaluation of truenat assays for the diagnosis of pulmonary and extrapulmonary tuberculosis: a systematic review and meta-analysis.
Expert Rev Anti Infect Ther
August 2024
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Background: Tuberculosis (TB) remains a significant global health concern, necessitating accurate and timely diagnostic methods. This study aimed to conduct a systematic review and meta-analysis to assess the diagnostic accuracy of Truenat assays for both pulmonary TB (PTB) and extrapulmonary TB (EPTB).
Method: PubMed, Scopus, and Web of Science were systematically searched for studies comparing Truenat assays to confirmation methods.
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