AI Article Synopsis
- The study examined the link between serum adenosine deaminase levels and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM), involving 459 participants.
- Significant differences in CAC scores were found among three groups classified by serum adenosine deaminase levels, with a positive correlation between these levels and CAC scores (r = 0.355, p < 0.001).
- Findings suggest that serum adenosine deaminase levels could serve as a useful clinical marker for assessing the severity of atherosclerosis in T2DM patients.
Article Abstract
We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930648 | PMC |
| http://dx.doi.org/10.1177/1076029621999722 | DOI Listing |
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