The preservation of DNA in biological samples is important for forensic testing, as samples can be tested years or even decades after collection. Generally, the DNA within biological evidence is stable over shorter time frames but can degrade over extended periods. In this work, we evaluated accelerated aging as a method to reduce the duration of studies examining the stability of DNA in forensic evidence-type samples. Evaluation of the DNA extracted from cells stored at 37 and 50°C for 194 or 79 days, respectively, showed similar quality metrics to cells stored at 25°C for 548 days.
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http://dx.doi.org/10.2144/btn-2020-0170 | DOI Listing |
J Clin Invest
January 2025
Growth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Posttranslational modification (PTM) of the amyloid precursor protein (APP) plays a critical role in Alzheimer's disease (AD). Recent evidence reveals that lactylation modification, as a novel PTM, is implicated in the occurrence and development of AD. However, whether and how APP lactylation contributes to both the pathogenesis and cognitive function in AD remains unknown.
View Article and Find Full Text PDFAdv Gerontol
January 2025
Research Medical Centre «Gerontology», 116, 1, 321 Volokolamskoe highway, Moscow 125371, Russian Federation.
The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.
View Article and Find Full Text PDFFront Aging
December 2024
Diabetes Research Program, Holman Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University School of Medicine, New York, NY, United States.
Human skin plays an important role protecting the body from both extrinsic and intrinsic factors. Skin aging at cellular level, which is a consequence of accumulation of irreparable senescent keratinocytes is associated with chronological aging. However, cell senescence may occur independent of chronological aging and it may be accelerated by various pathological conditions.
View Article and Find Full Text PDFPsychophysiology
January 2025
Fudan Institute on Ageing, Fudan University, Shanghai, China.
It is common to make risky decisions under time pressure. However, there are ongoing debates regarding the interpretation of the intrinsic mechanisms through which time pressure influences risky decision-making. The current study, combining a sequential risk-taking task, behavioral modeling, and time-resolved multivariate pattern analysis on electroencephalography signals, explored the intrinsic mechanisms underlying the influence of time pressure on risky decision-making.
View Article and Find Full Text PDFPLoS One
December 2024
School of Civil Engineering and Architecture, Wuhan Institute of Technology, Wuhan, Hubei, China.
The declining birth rate is one of the world's major challenges. There is much literature on birth rate research in China. However, there are few studies on spatial distribution and influencing factors of birth rate in the Yangtze River Basin.
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