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Progenitor cell diversity in the developing mouse neocortex. | LitMetric

Progenitor cell diversity in the developing mouse neocortex.

Proc Natl Acad Sci U S A

Department of Human Genetics, The University of Chicago, Chicago, IL 60637;

Published: March 2021

AI Article Synopsis

Article Abstract

In the mammalian neocortex, projection neuron types are sequentially generated by the same pool of neural progenitors. How neuron type specification is related to developmental timing remains unclear. To determine whether temporal gene expression in neural progenitors correlates with neuron type specification, we performed single-cell RNA sequencing (scRNA-Seq) analysis of the developing mouse neocortex. We uncovered neuroepithelial cell enriched genes such as and when compared to radial glial cells (RGCs). RGCs display dynamic gene expression over time; for instance, early RGCs express higher levels of , and late RGCs show higher expression of Interestingly, intermediate progenitor cell marker gene coexpresses temporally with known neuronal identity genes at different developmental stages, though mostly in postmitotic cells. Our results delineate neural progenitor cell diversity in the developing mouse neocortex and support that neuronal identity genes are transcriptionally evident in -positive cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958455PMC
http://dx.doi.org/10.1073/pnas.2018866118DOI Listing

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