AI Article Synopsis
- Obesity is a leading cause of insulin resistance, contributing to the rising rates of type 2 diabetes mellitus (T2DM) due to the associated chronic inflammation.
- Recent studies highlight how obesity-induced inflammation affects key metabolic tissues, particularly emphasizing the impacts of adipose tissue hypoxia and exosomes from macrophages.
- The review also explores current and emerging therapies aimed at modifying the immune response to address these metabolic issues.
Article Abstract
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic dysfunction in obesity. Here, we summarize recent advances in our understanding of immunometabolism. We discuss the characteristics of chronic inflammation in the major metabolic tissues and how obesity triggers these events, including a focus on the role of adipose tissue hypoxia and macrophage-derived exosomes. Last, we also review current and potential new therapeutic strategies based on immunomodulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919414 | PMC |
| http://dx.doi.org/10.1101/gad.346312.120 | DOI Listing |
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