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Dysregulation of Airway and Systemic Interferon Responses Promote Asthma Exacerbations in Urban Children.
J Allergy Clin Immunol
January 2025
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Background: Determining why some upper respiratory illnesses provoke asthma exacerbations remains an unmet need.
Objective: To identify transcriptome-wide gene expression changes associated with colds that progress to exacerbation.
Methods: 208 urban children (6-17 years) with exacerbation-prone asthma were prospectively monitored for up to two cold illnesses.
[Screw Angle and Condylar Ratio as Possible Parameters to Monitor the Treatment of Idiopathic Axial lower Limb Deformities Using Eight-Figure Plates].
Acta Chir Orthop Traumatol Cech
January 2025
Klinika dětské chirurgie, ortopedie a traumatologie Fakultní nemocnice Brno.
Purpose Of The Study: Temporary hemiepiphyseodesis using figure-eight plates is currently one of the main surgical techniques to correct axial deformities of lower limbs in paediatric patients. Comprehensive analysis, correct indication and monitoring of treatment are the basic prerequisites for successful therapy. The aim of the study was to analyse parameters that could become an alternative to standard parameters used nowadays, namely the inserted screw angle (SA), and a new parameter - condylar ratio (CR).
View Article and Find Full Text PDFAssessment of Humoral Response at SARS-CoV-2 Infection by Multipronged Functional Proteomics Approaches.
J Proteome Res
January 2025
Translational and Clinical Research Program, Cancer Research Center (IBMCC, CSIC-University of Salamanca), Cytometry Service, NUCLEUS, Department of Medicine, University of Salamanca, 37008 Salamanca, Spain.
In the past decade, a major goal in biomedical research has been to understand why individuals differ in disease susceptibility, disease dynamics, and progression. In many pathologies, this variability stems from evolved immune mechanisms that resist inflammatory stress from various diseases that have been encountered throughout life. These may provide advantages against other diseases, reduce comorbidities, and enhance longevity.
View Article and Find Full Text PDFManagement of Ventilator-Associated Pneumonia Caused by and Organisms in a Pediatric Center: A Randomized Controlled Study.
Medicina (Kaunas)
December 2024
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
A dangerous infection contracted in hospitals, ventilator-associated pneumonia is frequently caused by bacteria that are resistant to several drugs. It is one of the main reasons why patients in intensive care units become ill or die. This research aimed to determine the most effective empirical therapy of antibiotics for better ventilator-associated pneumonia control and to improve patient outcomes by using the minimal inhibitory concentration method and the Ameri-Ziaei double antibiotic synergism test and by observing the clinical responses to both single and combination therapies.
View Article and Find Full Text PDFAntimicrobial Susceptibility Profiles of Commensal Isolates from Chickens in Hungarian Poultry Farms Between 2022 and 2023.
Antibiotics (Basel)
December 2024
Department of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, 1078 Budapest, Hungary.
Widespread use of antibiotics has led to a global increase in resistance. The bacterium is a facultative pathogen that often develops antibiotic resistance and is easily transmitted, not only in animal health but also in public health. Within the poultry sector, domestic fowl is widespread and one of the most dynamically growing sectors, which is why regular, extensive monitoring is crucial.
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