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| http://dx.doi.org/10.1016/j.molp.2021.02.009 | DOI Listing |
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Phosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression.
Open Biol
December 2024
Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Approximately 10-15% of human cancers are telomerase-negative and maintain their telomeres through a recombination-based process known as the alternative lengthening of telomeres (ALT) pathway. Loss of the alpha-thalassemia/mental retardation, X-linked (ATRX) chromatin remodeller is a common event in ALT-positive cancers, but is generally insufficient to drive ALT induction in isolation. We previously demonstrated that ATRX binds to the MRN complex, which is also known to be important in the ALT pathway, but the molecular basis of this interaction remained elusive.
View Article and Find Full Text PDFTIFAB Modulates Metabolic Pathways in KMT2A::MLLT3-Induced AML Through HNF4A.
Blood Adv
December 2024
Case Western Reserve University, Cleveland, Ohio, United States.
Article Synopsis
- TIFAB (TRAF-interacting protein with forkhead-associated domain B) is an inhibitor of NF-kB signaling that plays significant roles in blood cell production and various blood cancers, including acute myeloid leukemia (AML).
- The study finds that deleting TIFAB in AML negatively affects leukemia stem/progenitor cell function, glucose consumption, and mitochondrial activity, while gene analysis shows reduced activity in key pathways such as MYC and glycolysis.
- HNF4A emerges as a crucial target of TIFAB, and restoring HNF4A levels can counteract the metabolic issues linked to TIFAB deficiency, emphasizing the importance of the TIFAB-HNF4A relationship in AML progression.
TIFA enhances glycolysis through E2F1 and promotes the progression of glioma.
Cell Signal
January 2025
Department of Oncology, Binzhou Medical University Hospital, Binzhou 256603, Shandong, China. Electronic address:
Objective: TRAF interacting protein with forkhead associated domain (TIFA) influence progression of many cancers. However, its role in glioma remains to be explored. This study investigated the function of TIFA in glioma.
View Article and Find Full Text PDFConserved linear motif within the immediate early protein ORF45 promotes its engagement with KSHV lytic cycle-promoting forkhead transcription factors, FOXK1 and FOXK2.
J Virol
October 2024
Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that can cause several cancers, such as Kaposi sarcoma and primary effusion lymphoma (PEL). We and others have recently demonstrated that Forkhead box (FOX) transcription factors can be dysregulated by KSHV, and they can affect KSHV infection. Herein, we focus on dissecting the role of two FOXK subfamily members, FOXK1 and FOXK2, in the KSHV life cycle.
View Article and Find Full Text PDFEngineered FHA domains can bind to a variety of Phosphothreonine-containing peptides.
Protein Eng Des Sel
January 2024
Tango Biosciences, 2201 W. Campbell Park Drive, Chicago, IL 60612-4092 USA.
Antibodies play a crucial role in monitoring post-translational modifications, like phosphorylation, which regulates protein activity and location; however, commercial polyclonal and monoclonal antibodies have limitations in renewability and engineering compared to recombinant affinity reagents. A scaffold based on the Forkhead-associated domain (FHA) has potential as a selective affinity reagent for this post-translational modification. Engineered FHA domains, termed phosphothreonine-binding domains (pTBDs), with limited cross-reactivity were isolated from an M13 bacteriophage display library by affinity selection with phosphopeptides corresponding to human mTOR, Chk2, 53BP1, and Akt1 proteins.
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