Objective: The current study assesses the effects of platelet-rich plasma-fibrin glue (PRP-FG) dressing along with oral vitamin E and C on wound healing and biochemical markers in patients with non-healing diabetic foot ulcers (non-healing DFU).
Methods: This randomized controlled trial was performed on 25 patients with non-healing DFU. Patients were treated with PRP-FG dressing plus oral vitamin E and C (intervention group) or PRP-FG dressing plus placebo (control group) for 8 weeks.
Results: Eight weeks after treatment, six wounds in the intervention group and two wounds in the control group were completely closed, and also wound size significantly reduced in both intervention and control groups ( < 0.05). This reduction in wound size was significantly greater in the intervention group compared to the control group ( = 0.019). Also, a significant decrease in prooxidant-antioxidant balance (PAB) , ESR, and hs-CRP was observed in the intervention group compared to the control group ( < 0.05).
Conclusion: Our results showed that PRP-FG dressing along with oral vitamin E and C could be used to increase wound healing in patients with non-healing DFU by enhancing the wound healing process and reducing oxidative stress.
Trial Registration: This trial is registered at ClinicalTrials.gov (CT.gov identifier: NCT04315909).
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/14712598.2021.1897100 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!