Background: The use of benzodiazepines (BZDs) causes delirium, especially in elderly people. For this reason, suvorexant has been recommended as the first-line hypnotic in elderly patients. The aim of this study was to determine whether the first-line use of suvorexant, instead of BZDs, decreases referrals for delirium in elderly patients.
Methods: Since May 2016 at Nagoya Ekisaikai Hospital, suvorexant has been recommended as the first-line hypnotic instead of BZDs. In May 2017, suvorexant was adopted as the first-line hypnotic. The number of delirium cases referred to psychiatry was compared among three consecutive periods: period A (May 2015-April 2016), during which BZDs were mainly used for insomnia; period B (May 2016-April 2017), during which the use of suvorexant was recommended instead of BZDs; and period C (May 2017-April 2018), during which suvorexant was principally adopted as the first-line hypnotic for insomnia. Potential confounding factors that may affect the development of delirium were also examined during the three periods.
Results: The number of delirium referral cases in elderly patients in each period decreased, from 133 in period A to 86 in period B and 53 in period C. The rate of delirium referral cases decreased significantly every year (P = 9.02 × 10 ). Almost no significant confounding factors other than hypnotics were detected during the three periods.
Conclusion: The referrals for delirium in elderly patients decreased significantly after the hypnotic was changed from BZDs to suvorexant.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/psyg.12672 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the pharmacist role in insomnia management and care provision: A scoping review.
J Am Pharm Assoc (2003)
December 2024
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, NSW, Australia; CIRUS Sleep and Chronobiology Research Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia.
Background: Insomnia is a highly burdensome sleep disorder, with a global prevalence of approximately 30% in adults. Insomnia has negative effects on daily functioning and can play a pivotal role in the development and progression of comorbid mental and physical disease. Therefore, appropriate and timely management is essential.
View Article and Find Full Text PDFA scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.
Explor Res Clin Soc Pharm
December 2024
College of Pharmacy, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- * A scoping review examined driving performance assessments related to BZRA use, analyzing 183 studies that featured various drugs, with zopiclone being the most researched.
- * Results showed that a significant number of studies found impairment in driving performance, with an emphasis on using certain measures like the Standard Deviation of Lateral Position (SDLP) in experimental settings, and biological detection methods in observational studies.
Alternative treatment in adolescent with anti-NMDA receptor encephalitis catatonia.
Neurocase
December 2024
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Article Synopsis
- An adolescent with ANMDAE and catatonia was treated with zolpidem after traditional treatments like benzodiazepines and ECT failed.
- ANMDAE presents with neuropsychiatric symptoms, including memory issues, seizures, and catatonia, which can lead to serious medical complications.
- Current guidelines offer limited options for treating catatonia in young patients who don't respond to standard treatments, and zolpidem may be a viable alternative.
Evaluation of the effectiveness of cognitive-behavioural therapy for insomnia delivered by nurses and physicians for patients in primary care (the NPD study): protocol for a cluster randomised controlled trial.
BMJ Open
October 2024
Son Espases University Hospital, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Balearic Islands, Spain.
Introduction: Insomnia is the most common sleep disorder, and it adversely impacts daily living and increases the risk of chronic and acute health problems. Of the few individuals who seek treatment for insomnia, most pursue help in primary care settings. The management of insomnia most commonly focuses on the prescription of hypnotics and sleep hygiene recommendations, although these are not the most effective treatments.
View Article and Find Full Text PDFPropofol, Triglycerides, and Acute Pancreatitis: A Multi-Center Epidemiologic Analysis.
Ann Am Thorac Soc
October 2024
Mayo Clinic Division of Pulmonary and Critical Care Medicine, Rochester, Minnesota, United States;
Article Synopsis
- Propofol is frequently used as a sedative for critically ill adults on mechanical ventilation, but its link to elevated triglyceride levels and acute pancreatitis remains unclear.
- The study observed over 11,000 ICU patients receiving propofol, finding that about 21.7% developed hypertriglyceridemia, and those with high triglycerides had a significantly increased risk of pancreatitis.
- Despite the association between triglyceride levels and pancreatitis, acute pancreatitis is rare in this population, suggesting other contributing factors may be involved.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!