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| http://dx.doi.org/10.7189/jogh.11.03022 | DOI Listing |
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The severity of COVID 19 symptoms has a direct correlation with lymphopenia, affecting natural killer (NK) cells. SARS-CoV-2 specific "memory" NK cells obtained from convalescent donors can be used as cell immunotherapy. In 2022 a phase I, dose-escalation, single center clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD3/CD56 NK cells against moderate/severe cases of COVID-19 (NCT04578210).
View Article and Find Full Text PDFComparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia.
Front Radiol
January 2025
Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Background: Dark-field chest radiography allows the assessment of the structural integrity of the alveoli by exploiting the wave properties of x-rays.
Purpose: To compare the qualitative and quantitative features of dark-field chest radiography in patients with COVID-19 pneumonia with conventional CT imaging.
Materials And Methods: In this prospective study conducted from May 2020 to December 2020, patients aged at least 18 years who underwent chest CT for clinically suspected COVID-19 infection were screened for participation.
Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response.
Front Immunol
January 2025
Axe de Recherche Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, QC, Canada.
Introduction: The innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated the impact of vaccination on innate cell activation by TLR7/8 agonist R848, as well as seasonal variations.
View Article and Find Full Text PDFLignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity.
ACS Appl Mater Interfaces
January 2025
Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin 14195, Germany.
Mucus is a complex hydrogel that acts as a defensive and protective barrier in various parts of the human body. The rise in the level of viral infections has underscored the importance of advancing research into mucus-mimicking hydrogels for the efficient design of antiviral agents. Herein, we demonstrate the gram-scale synthesis of biocompatible, lignin-based virus-binding inhibitors that reduce waste and ensure long-term availability.
View Article and Find Full Text PDFOver the past 30 years, the relationship between the neighbouring states of Armenia and Türkiye has been greatly influenced by a politicised atmosphere and ongoing debates about their shared history, alongside efforts at reconciliation. It is noteworthy that, in a global context increasingly characterised by both anthropogenic and natural calamities, the phenomenon of (shared) disasters as it pertains to the dynamics of Armenia-Türkiye relations has garnered relatively scant scholarly attention. This study investigates instances of the COVID-19 (coronavirus disease 2019) pandemic on a global scale and the Kahramanmaraş (Türkiye) earthquakes that occurred on 6 February 2023, which serve as disasters possessing diplomatic and symbolic significance that could facilitate a transition from a state of conflict to one of cooperative peace between these two nations.
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