The corneal endothelium is the posterior monolayer of cells that are responsible for maintaining overall transparency of the avascular corneal tissue via pump function. These cells are non-regenerative in vivo and therefore, approximately 40% of corneal transplants undertaken worldwide are a result of damage or dysfunction of endothelial cells. The number of available corneal donor tissues is limited worldwide, hence, cultivation of human corneal endothelial cells (hCECs) in vitro has been attempted in order to produce tissue engineered corneal endothelial grafts. Researchers have attempted to recreate the current gold standard treatment of replacing the endothelial layer with accompanying Descemet's membrane or a small portion of stroma as support with tissue engineering strategies using various substrates of both biologically derived and synthetic origin. Here we review the potential biomaterials that are currently in development to support the transplantation of a cultured monolayer of hCECs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894589 | PMC |
| http://dx.doi.org/10.1177/2041731421990536 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty.
Invest Ophthalmol Vis Sci
January 2025
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Descemet membrane endothelial keratoplasty (DMEK) has emerged as a novel approach in corneal transplantation over the past two decades. This study aims to identify predisposing risk factors for post-DMEK ocular hypertension (OHT) and develop a preoperative predictive model for post-DMEK OHT.
Methods: Patients who underwent DMEK at Gangnam Severance Hospital between 2017 and 2024 were included in the study.
Biomimetic Air-Lifted Organ Culture System with a Protective Coverage Membrane for Full-Thickness Corneal Preservation.
ACS Biomater Sci Eng
January 2025
Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Effective storage and utilization of limited donor corneal resources are in high demand to alleviate the shortage of donor corneal tissue. Here, we designed a static air-lifted organ culture system equipped with a protective coverage membrane, namely, an air-lifted OC-P system, to provide a biomimetic physiological environment for full-thickness corneal preservation. The air-lifted OC-P system features a unique collagen-based protective coverage membrane that can offer a moist, oxygen-rich environment for corneal epithelium, produce an appropriate intraocular pressure onto the cornea by gravity, and facilitate the maintenance of the organ culture medium level for nutrient supply during corneal preservation.
View Article and Find Full Text PDFCorneal Confocal and Specular Microscopic Characteristics in Primary Open-Angle Glaucoma: An Optical Coherence Tomography (OCT)-Based Case-Control Study.
Cureus
December 2024
Cornea and Refractive Surgery, Al-Shifa Trust Eye Hospital, Rawalpindi, PAK.
Background: Glaucoma, particularly open-angle glaucoma (OAG), is a leading cause of irreversible blindness, associated with optic nerve damage, retinal ganglion cell death, and visual field defects. Corneal biomechanical properties and cellular components, such as corneal nerve and keratocyte densities assessed by in vivo confocal microscopy (IVCM), may serve as biomarkers for glaucoma progression. This study aimed to explore the relationship between corneal nerve parameters, keratocyte density, and optical coherence tomography (OCT)-derived retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) patients and controls.
View Article and Find Full Text PDF[Development and validation of a risk prediction model for early postoperative high intraocular pressure after implantation of posterior chamber intraocular lens].
Zhonghua Yi Xue Za Zhi
January 2025
Ophthalmology Center, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou310009, China.
To develop and validate a predictive model for assessing the risk of early postoperative high intraocular pressure (HIOP) following posterior chamber intraocular lens implantation. The clinical data of patients who underwent posterior chamber intraocular lens implantation at the Second Affiliated Hospital of Zhejiang University School of Medicine between May 2023 and April 2024 were retrospectively reviewed. Patients were divided into a modeling group and a validation group with a 7∶3 ratio using computerized random allocation.
View Article and Find Full Text PDFEvaluation of corneal incision in femtosecond laser-assisted phacoemulsification.
Clinics (Sao Paulo)
January 2025
Horta Institute, Rio de Janeiro, Brazil.
Purpose: This study aimed to evaluate the accuracy and quality of healing of main corneal incisions in femtosecond laser procedures in cataract surgery.
Methods: It was a prospective, non-randomized, investigator-masked study. A total of 37 eyes of 37 patients with indication for cataract surgery were separated into two groups in this prospective, nonrandomized study: Femto group, with incisions automated by femtosecond laser (18 eyes), and Phaco group, with incisions made using a keratome (19 eyes).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!