AI Article Synopsis
- * The presence of immune cells in CRC tumors and their liver metastases can help predict how the disease will progress and how long patients may survive.
- * Effective studies on immunotherapies for CRC require preclinical models that accurately mimic the cancer's tumor microenvironment, including various types of cells and structures, with a review of current research models highlighting their strengths and weaknesses.
Article Abstract
Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death in the US. CRC frequently metastasizes to the liver and these patients have a particularly poor prognosis. The infiltration of immune cells into CRC tumors and liver metastases accurately predicts disease progression and patient survival. Despite the evident influence of immune cells in the CRC tumor microenvironment (TME), efforts to identify immunotherapies for CRC patients have been limited. Here, we argue that preclinical model systems that recapitulate key features of the tumor microenvironment-including tumor, stromal, and immune cells; the extracellular matrix; and the vasculature-are crucial for studies of immunity in the CRC TME and the utility of immunotherapies for CRC patients. We briefly review the discoveries, advantages, and disadvantages of current and model systems, including 2D cell culture models, 3D culture systems, murine models, and organ-on-a-chip technologies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902698 | PMC |
| http://dx.doi.org/10.3389/fimmu.2020.614300 | DOI Listing |
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