Background And Aim: Interest in plants with antimicrobial properties has been revived due to emerging problems associated with using antibiotics to eradicate . Accordingly, this study aims to assess the antibacterial effects of and the possible synergistic effect of its extract along with metronidazole against .
Materials And Methods: Pomegranate peel ethanol extracts (PPEE) was tested against a control strain of (NCTC 11916) and in female Wistar rats. Moreover, the synergistic effect of PPEE in combination with metronidazole was tested .
Results: The PPEE exhibited a remarkable activity against with a minimum inhibitory concentration (MIC) of 0.156 mg/mL. Furthermore, the extract exhibited a pronounced urease inhibitory activity (IC ~6 mg/mL) against the tested strain. A synergistic effect between PPEE and metronidazole was also observed (fractional inhibitory concentrations <0.5). Oral treatment of rats with PPEE for 8 days produced a significant reduction in gastritis and a significant decrease in both lymphocytic and positive chronicity.
Conclusion: Pomegranate extract is probably safe and represents a potential alternative and complementary therapy for reducing associated with gastric ulcers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896906 | PMC |
| http://dx.doi.org/10.14202/vetworld.2021.120-128 | DOI Listing |
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