Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343301 | PMC |
| http://dx.doi.org/10.4103/1673-5374.308087 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hypoxia-induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation.
FEBS J
December 2024
School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Critical limb ischemia (CLI) is the most advanced stage of peripheral arterial disease, posing a high risk of mortality. Sphingomyelin, a sphingolipid synthesized by sphingomyelin synthases (SMSs) 1 and 2, plays an essential role in signal transduction as a component of lipid rafts. However, the role of sphingomyelin in the inflammation of ischemic skeletal muscles remains unclear.
View Article and Find Full Text PDFThe lysosomal storage diseases chronic visceral acid sphingomyelinase deficiency (ASMD) and Gaucher disease type 1 (GD1) are both macrophage storage disorders with overlapping clinical manifestations. We compared cross-sectional data on visceral, hematological, and biochemical manifestations of untreated adult patients with chronic visceral ASMD ( = 19) and GD1 ( = 85). Spleen volume, liver volume, and bone marrow fat fraction did not significantly differ between the two disease groups ( >0.
View Article and Find Full Text PDFMetabolomics Approach to Identify Biomarkers of Acute and Subacute Mastitis in Milk Samples: A Pilot Case-Control Study.
Metabolites
October 2024
LactApp Women Health, 08014 Barcelona, Spain.
Article Synopsis
- Mastitis is a common breastfeeding complication that can lead to stopping breastfeeding, and the study aims to identify metabolic changes in breast milk as potential biomarkers for acute and subacute mastitis.
- A pilot study analyzed milk samples from 14 women with acute mastitis, 32 with subacute symptoms, and 19 controls using a proton NMR approach, identifying 40 metabolites.
- Key findings indicated that acute mastitis was linked to elevated levels of acetate and cholesterol, while subacute mastitis showed significant associations with various lipids, highlighting cholesterol and polyunsaturated fatty acids as potential biomarkers for both types of mastitis.
A myeloid differentiation-like protein in partnership with Toll5 from the pest insect senses baculovirus infection.
Proc Natl Acad Sci U S A
October 2024
Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou 510631, China.
Many types of viruses infect insects and other arthropods. In contrast, little is known about how arthropods sense viruses, although several innate immune pathways including Toll have antiviral functions. Large DNA viruses in the family are used to control a number of pest insects.
View Article and Find Full Text PDFUnexpected asymmetric distribution of cholesterol and phospholipids in equilibrium model membranes.
Biophys J
November 2024
Department of Chemical Engineering, University of Illinois at Chicago, Chicago, Illinois. Electronic address:
Lipid compositional asymmetry across the leaflets of the plasma membrane is an ubiquitous feature in eukaryotic cells. How this asymmetry is maintained is thought to be primarily controlled by active transport of lipids between leaflets. This strategy is facilitated by the fact that long-tail phospholipids and sphingolipids diffuse through the lipid bilayer slowly-taking many hours or days.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!