Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935666 | PMC |
| http://dx.doi.org/10.1016/j.hoc.2021.01.002 | DOI Listing |
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