Diacylphloroglucinol derivatives as antioxidant agents: green synthesis, optimisation, , and evaluation.

Several derivatives of diacylphloroglucinol ( and ) as an analogue of natural product compound 2,4-diacetylphloroglucinol , were successfully synthesised in an excellent yield a greener Friedel-Craft acylation using methanesulfonic acid (MSA) as a catalyst under an ultrasound-assisted condition. Operational simplicity, excellent yield, expedient metal-free synthesis, energy-efficient and mild reaction conditions are the outstanding advantages in this procedure. A scaled-up reaction also revealed the practical suitability of this newly developed procedure. The effects of several process variables on were carefully accomplished using response surface methodology (RSM). Moreover, the green credentials of the present protocol have been assessed using several established green metrics and compared to relevant procedures. Along with the monomers, dimeric diacylphloroglucinols () were also synthesised and their antioxidant activity of these species were carried out. Furthermore, drug-likeness, density functional theory (DFT), and molecular docking studies were also established.