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| http://dx.doi.org/10.1038/s41392-021-00511-9 | DOI Listing |
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Post-COVID Mucormycosis-Conceptual Etiology and New Treatment Options.
J Maxillofac Oral Surg
December 2024
Radix Clinic, Vadodara, Gujarat 390021 India.
Article Synopsis
- COVID-19, caused by SARS-CoV-2, increases the risk of opportunistic infections like mucormycosis, particularly in patients with conditions such as diabetes or those receiving immunosuppressive treatments.
- New research indicates that post-COVID mucormycosis can occur in young, non-diabetic patients, potentially linked to factors like coagulopathy and microembolism that allow fungi to invade.
- A proposed treatment strategy combines antifungal medications with fibrinolytic agents to address microcoagulopathy, leading to better recovery and healing outcomes for those affected by post-COVID mucormycosis.
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.
Nat Commun
March 2024
Integrated Biomedical Sciences, University of Notre Dame, Notre Dame, IN, 46556, USA.
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections.
View Article and Find Full Text PDFFibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.
Res Sq
September 2023
Integrated Biomedical Sciences, University of Notre Dame, IN 46556, USA.
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat due to multi-drug resistance development among the CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections.
View Article and Find Full Text PDFNrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.
Commun Biol
August 2023
Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Article Synopsis
- Spaceflight can lead to health issues, affecting various systems like the immune system, with oxidative stress playing a key role.
- Research on Nrf2-knockout mice showed they experienced worse immunosuppression and inflammation from spaceflight compared to normal mice.
- The findings suggest that enhancing Nrf2 activity could help alleviate health challenges faced by astronauts during space travel.
Proteomic and Biological Analysis of an Human Endothelial System in Response to Drug Anaphylaxis.
Front Immunol
December 2021
Allergy and Inmunology Department, Instituto de Investigaciones Sanitarias (ISS)-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Anaphylaxis is a life-threatening systemic hypersensitivity reaction. During anaphylaxis, mediator release by effector cells causes endothelial barrier breakdown, increasing vascular permeability and leakage of fluids, which may lead to tissue edema. Although endothelial cells (ECs) are key players in this context, scant attention has been paid to the molecular analysis of the vascular system, and further analyses of this cell type are necessary, especially in humans.
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