In both criminal cases and civil cases there is an increasing demand for the analysis of DNA mixtures involving relationships. The goal might be, for example, to identify the contributors to a DNA mixture where the unknown donors may be related, or to infer the relationship between individuals based on a DNA mixture. This paper applies a new approach to modelling and computation for DNA mixtures involving contributors with arbitrarily complex relationships to two real cases from the Spanish Forensic Police.
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http://dx.doi.org/10.1016/j.fsigen.2021.102482 | DOI Listing |
Pharm Res
January 2025
Synthetic Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Purpose: The purpose of this study is to present a correlative microscopy-tomography approach in conjunction with machine learning-based image segmentation techniques, with the goal of enabling quantitative structural and compositional elucidation of real-world pharmaceutical tablets.
Methods: Specifically, the approach involves three sequential steps: 1) user-oriented tablet constituent identification and characterization using correlative mosaic field-of-view SEM and energy dispersive X-ray spectroscopy techniques, 2) phase contrast synchrotron X-ray micro-computed tomography (SyncCT) characterization of a large, representative volume of the tablet, and 3) constituent segmentation and quantification of the imaging data through user-guided, iterative supervised machine learning and deep learning.
Results: This approach was implemented on a real-world tablet containing 15% API and multiple common excipients.
Chemosphere
January 2025
HydroSciences Montpellier, University of Montpellier, IRD, CNRS, 15 Av. Charles Flahault, 34090, Montpellier, France.
Water scarcity in the Mediterranean area has increased the number of intermittent rivers. Recently, hyporheic zones (HZ) of intermittent rivers have gained attention since a substantial part of the stream's natural purification capacity is located within these zones. Thus, understanding the flow dynamics in HZs is crucial for gaining insights into the degradation of organic micropollutants.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Univ. Bordeaux, CNRS, Bordeaux INP, EPOC, UMR 5805, Pessac F-33600, France. Electronic address:
Plastic products contain complex mixtures of chemical compounds that are incorporated into polymers to improve material properties. Besides the intentional chemical additives, other compounds including residual monomers and non-intentionnaly added substances (NIAS) as well as sorbed pollutants are usually also present in aged plastic. Since most of these substances are only loosely bound to the polymer via non-covalently interactions, i.
View Article and Find Full Text PDFPlacenta
December 2024
Johns Hopkins University Bloomberg School of Public Health, USA. Electronic address:
Chronic arsenic exposure affects over 140 million people globally. While arsenic easily crosses the placenta, the specific mechanisms impacting placental immune cell populations and fetal health are unclear. Maternal arsenic exposure is epidemiologically linked to increased infection risk, mortality, and cancer susceptibility in offspring, emphasizing the importance of understanding placentally-mediated immune effects.
View Article and Find Full Text PDFToxics
December 2024
Aquatic Contaminants Research Division, Environment and Climate Change Canada, 105 McGill, Montréal, QC H2Y 2E7, Canada.
Rare earth elements (REEs) are considered as emerging contaminants due to their use in the fabrication process of current technologies. As such, their aquatic toxicity, especially as a mixture, is not well understood, as it has been scarcely investigated. The purpose of this study was to shed light on the sublethal and lethal toxicity of a realistic mixture of five REE in .
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