Inference on tissue transplantation experiments.

J Theor Biol

Institut des Hautes Études Scientifiques (IHÉS), 91440 Bures-sur-Yvette, France; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, 91198 Gif-sur-Yvette, France; Komarov Botanical Institute, Russian Academy of Sciences (BIN RAS), 197376 Saint Petersburg, Russia.

Published: July 2021

We review studies on tissue transplantation experiments for various species: one piece of the donor tissue is excised and transplanted into a slit in the host tissue, then observe the behavior of this grafted tissue. Although we have known the results of some transplantation experiments, there are many more possible experiments with unknown results. We develop a penalty function-based method that uses the known experimental results to infer the unknown experimental results. Similar experiments without similar results get penalized and correspond to smaller probability. This method can provide the most probable results of a group of experiments or the probability of a specific result for each experiment. This method is also generalized to other situations. Besides, we solve a problem: how to design experiments so that such a method can be applied most efficiently.

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Source
http://dx.doi.org/10.1016/j.jtbi.2021.110645DOI Listing

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