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Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
Onco Targets Ther
January 2025
Tianjin Medical University, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Disease, Tian Jin, People's Republic of China.
Objective: To explore the relationship and underlying mechanisms between vitamin D and CRC, offering valuable insights into the diagnosis and treatment of CRC.
Materials And Methods: Serum levels of 1,25(OH)D were measured using a double-antibody sandwich assay. Bioinformatics analysis identified vitamin D-related CRC genes, which were validated using HCT116 and HT29 cell lines.
Fecal methylated syndecan-2 () testing for early screening of colorectal cancerous and precancerous lesions: A real-world retrospective study in China.
Cancer Pathog Ther
January 2025
Cancer Pathogenesis and Therapy, Chinese Medical Association Publishing House, Beijing 100052, China.
Background: Colorectal cancer (CRC) is a major public health concern and the second leading cause of cancer-related deaths worldwide. However, challenges remain in deploying effective screening strategies for early-stage CRC. This study aimed to evaluate the effectiveness of a fecal-based syndecan-2 () methylation test for the detection of colorectal lesions and CRC.
View Article and Find Full Text PDFLong-term colorectal cancer incidence in a post-endoscopic screening cohort, accounting for surveillance, by baseline polyp group, anatomic subsite, and sex.
J Med Screen
January 2025
Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.
Objectives: Colonoscopy surveillance is often performed in post-polypectomy cohorts, likely altering colorectal cancer (CRC) outcomes, but this is often not addressed in CRC incidence analyses. We examined CRC incidence post-endoscopic screening, accounting for surveillance.
Methods: We examined UK Flexible Sigmoidoscopy Screening Trial participants who had no, low-risk, or high-risk (≥10 mm, ≥3 adenomas, adenomas with villous features/high-grade dysplasia) distal polyps at screening.
The Clinical Diagnostic Value of the Super-enhancer-associated Long Noncoding RNA RP11-803D5.4 and AC005592.2 in Colorectal Cancer.
Curr Med Chem
January 2025
Department of Clinical Laboratory, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Baiziting No. 42, Nanjing, 210009, China.
Background: Super-enhancer-associated long noncoding RNAs (SE-lncRNAs) play crucial roles in CRC pathogenesis.
Objective: RP11-803D5.4 and AC005592.
A Community Initiative to Increase Colorectal Cancer Knowledge, Awareness, and Intent to Screen in an Underserved Region.
J Dr Nurs Pract
January 2025
Texas A&M University, Corpus Christi, TX, USA.
Colorectal cancer (CRC) is a leading cause of cancer-related deaths in the United States despite the availability of effective preventive screening. This project was designed as a community awareness initiative to increase CRC awareness, knowledge, and intent to discuss and complete CRC screening. This quasi-experimental study had a QI focus and used a convenience sample in a public setting assessing CRC awareness, knowledge, and intent to discuss and complete screening after participating in an inflatable colon tour.
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