[Rossolimo-Melkersson-Rosenthal syndrome].

Vestn Dermatol Venerol

Published: June 1988

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The article describes Rossolimo-Melkersson-Rosenthal disease (RMRD); historical background and the modern concept of its pathogenesis are presented in brief. The clinical picture of the disease is described in more detail; the variants of the course of the disease and the manifestations of the monosymptomatic, bisymptomatic, and triadic variants are presented. The article contains a clinical observation of a female patient aged 38, whose first symptoms developed at the age of 18 as facial neuritis and left mimic musculature paresis.

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Clinical oral symptoms were studied in 210 patients with the Rossolimo-Melkersson-Rosenthal syndrome (RMRS); the immune status was evaluated in 17 of these. Oral status was characterized by high prevalence and intensity of caries and presence of chronic generalized periodontitis. Immunological studies revealed changes characteristic of immunodeficiency: increased counts of suppressor cytotoxic T-lymphocytes, decreased phagocytic activity of neutrophils, and dysimmunoglobulinemia; hence, RMRS was associated with secondary immunodeficiency.

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