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| http://dx.doi.org/10.37201/req/123.2020 | DOI Listing |
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Ventriculoperitoneal shunt in the treatment of cryptococcal meningitis with intracranial hypertension.
J Infect Dev Ctries
December 2024
Department of Neurosurgery, The third affiliated hospital, Sun Yat-Sen University, Guangzhou, China.
Introduction: Cryptococcal meningitis (CM) combined with intracranial hypertension is associated with a poor prognosis. This study aimed to investigate the therapeutic efficacy and prognostic factors of ventriculoperitoneal (VP) shunt in non-human immunodeficiency virus (HIV) CM patients with intracranial hypertension.
Methodology: A total of 136 non-HIV CM patients with intracranial hypertension treated in our hospital from July 2010 to December 2019 were retrospectively included.
The fluoroquinolone compounds potentiate the antifungal activity of the echinocandins against Aspergillus fumigatus.
Biosci Rep
January 2025
Korea University, Seoul, Korea (South), Republic of.
The antifungal drugs of the echinocandin family show high efficacy against Aspergillus fumigatus. However, their paradoxical effect, which restores fungal growth at high drug concentrations, and the emergence of resistant strains necessitate improvements. We identified 13 fluoroquinolone compounds from a chemical library containing 10,000 compounds that potentiate the antifungal activity of caspofungin.
View Article and Find Full Text PDFFungal infections cause millions of deaths annually and are challenging to treat due to limited antifungal options and increasing drug resistance. Cryptococci are intrinsically resistant to the latest generation of antifungals, echinocandins, while , a notorious global threat, is also increasingly resistant. We performed a natural product extract screen for rescue of the activity of the echinocandin caspofungin against H99, identifying butyrolactol A, which restores echinocandin efficacy against resistant fungal pathogens, including .
View Article and Find Full Text PDFPersistent NK cell deficiency associated with pulmonary cryptococcosis.
Ann Clin Microbiol Antimicrob
January 2025
Marseille University Hospital Timone, Public Assistance Marseille Hospitals, Marseille Immunopole, Marseille, France.
We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.
View Article and Find Full Text PDFInvasive Fungal Diseases in Patients with Multiple Myeloma: Experience at a Large, Urban Referral Center.
Transpl Infect Dis
January 2025
Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: Although infections are a leading cause of morbidity and mortality among patients with multiple myeloma (MM), the epidemiology of invasive fungal disease (IFD) is less well characterized in this population than in other hematologic malignancies.
Methods: We conducted a nested 3:1 case-control study of IFD at a large MM referral center to identify risk factors for IFD in this population.
Results: In a cohort of 2960 patients, we identified 32 episodes of IFD among 31 patients between 01/2011 and 06/2019.
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