AI Article Synopsis
- The study investigates the link between serotonin transporter genetic variations (5-HTTLPR and 5-HTTVNTR) and mood disorders in patients suffering from temporal lobe epilepsy related to hippocampal sclerosis (TLE-HS).
- A total of 119 TLE-HS patients, 146 individuals with major depressive disorder (MDD), and 113 healthy controls were genotyped; results showed no significant differences among groups regarding mood disorders.
- While the serotonin transporter variants did not associate with depressive disorder in TLE-HS patients, a specific variation (12-allele of 5-HTTVNTR) was linked to family history of epilepsy, indicating its
Article Abstract
Background: Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms - 5-HTTLPR and 5-HTTVNTR - and the presence of mood disorders in patients with TLE-HS.
Methods: We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were genotyped for the 5-HTTLPR and 5-HTTVNTR polymorphisms.
Results: No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013).
Conclusions: In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics.
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| http://dx.doi.org/10.1016/j.yebeh.2021.107854 | DOI Listing |
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