AI Article Synopsis
- The study investigates if maternal autoimmune diseases or medication during pregnancy increases cancer risk in offspring.
- The research analyzed data from over 2,000 young cancer patients and 10,000 controls to assess the correlation.
- Findings showed no significant increase in cancer risk for the offspring, even suggesting a decreased risk in some cases, particularly when medication was involved.
Article Abstract
Aim: Autoimmune disease and its medication are associated with increased cancer risk in adults, but it is unknown whether maternal autoimmune disease and/or medication use in pregnancy are associated with increased cancer risk in offspring.
Methods: In this case-control study, we identified all patients under 20 years of age with their first cancer diagnosis in 1996-2014 from the Finnish Cancer Registry (n = 2029) and 1:5 population-based controls (n = 10,103) from the Medical Birth Register. We obtained information on maternal autoimmune disease and its medication from the relevant Finnish registries and used conditional logistic regression to analyse the risk of offspring cancer after maternal autoimmune disease exposure.
Results: The odds ratio (OR) for cancer in offspring following maternal autoimmune exposure was 0.76 (95% confidence interval [CI] 0.47-1.23). Individual ORs for inflammatory bowel and connective tissue diseases were 1.08 (95% CI 0.56-2.01) and 0.50 (95% CI 0.23-1.08), respectively. The OR for maternal autoimmune medication was 0.95 (95% CI 0.80-1.14) overall and similar by drug subtype. There was an increased risk with medication in late pregnancy but the ORs were unstable owing to small numbers.
Conclusion: Our study does not support an increased cancer risk among offspring of women with autoimmune disease or its medication during pregnancy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270501 | PMC |
| http://dx.doi.org/10.1111/apa.15821 | DOI Listing |
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