AI Article Synopsis
- Chlorhexidine is a synthetic compound with strong antibacterial properties but can cause severe allergic reactions during surgical procedures, known as perioperative anaphylaxis.
- A case study of a 36-year-old man highlighted the importance of in-vitro tests, like specific IgE detection and basophil activation tests, for diagnosing chlorhexidine allergies, especially when skin tests may yield misleading results.
- The findings suggest that doctors need to recognize the potential risks of chlorhexidine and utilize advanced lab testing methods when skin test results are inconclusive for diagnosing allergies.
Article Abstract
Background: Chlorhexidine is a synthetic biguanide with a broad antibacterial activity and has become an important cause of perioperative anaphylaxis.
Objective: Reactions due to chlorhexidine allergy are usually IgE-mediated. The aim of this report is to demonstrate utility of laboratory in-vitro testing for diagnosis.
Methods: We report the case of a 36-year old man who experienced severe anaphylaxis during general anesthesia. He underwent skin tests, specific detection of specific IgE to chlorhexidine and basophil activation test (BAT).
Results: Skin tests gave false positive results due to dermographism. So, on the basis of a clinical reaction to chlorhexidine and positive tests for IgE to chlorexidine and BAT, we assessed the diagnosis of chlorhexidine allergy.
Conclusions: Physicians should be aware of the role of chlorhexidine in the etiology of perioperative anaphylaxis. In vitro testing such specific IgE and BAT are useful in patient with suspected chlorexidine allergy and limitation to perform skin tests.
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Source |
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| http://dx.doi.org/10.12932/AP-250620-0890 | DOI Listing |
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